The course places the use and development of artificial intelligence (AI) in a social, political, and global context. Integrating theories, empirical research, and diverse perspectives, the course focuses on key challenges that the adoption and adaptation of AI pose to global leadership in the fourth industrial revolution. The main scope of the course is to build understanding of how ethics, technology, and culture play into social development, adaptation, and change, while considering inequities and asymmetrical relations. The course proposes hands-on innovative approaches to understanding these challenges and finding solutions that are operationally sound in local to global contexts, systems thinking oriented, ethically and politically aware, and culturally sensitive.